2004 Region III
All-Region Team
| Offensive Player of the Year |
| Vic Hall - Gretna |
| Defensive Player of the Year |
| Darryl Gresham - William Fleming |
Offense
First Team
| QB | Vic Hall | Gretna |
| RB | Kevin Crouse | Pulaski County |
| RB | Jonathan Rose | Amherst County |
| RB | Billy Ray Welch | William Byrd |
| WR | Paul Debnam | Prince Edward Co. |
| WR | Boscoe Williams | Alleghany |
| TE | David Redick | Cave Spring |
| C | Aaron Israel | Amherst County |
| G | Chris Moore | Amherst County |
| G | Sergio Jones | Northside |
| T | Larrel Baines | Gretna |
| T | Tommy Burgess | Cave Spring |
| K | Cliff Stanley | Liberty |
| KR | Mijuan Curtis | William Fleming |
Defense
First Team
| DL |
Kasey McCambridge |
Pulaski County |
| DL | Derrick Jones | Liberty |
| DL | Isaiah Gears | William Fleming |
| DE | Dewayne Hubbard | Gretna |
| DE | Ernie Hodge | Pulaski County |
| LB | Darryl Gresham | William Fleming |
| LB | Patrick Parziale | Jefferson Forest |
| LB | Collin McConaghy | Amherst County |
| LB | Jonas Rawlings | Salem |
| DB | O.B. Blake | Liberty |
| DB | Dwayne Priest | William Fleming |
| DB | Alonzo Poe | Amherst County |
| DB | Bryan Webb | Salem |
| P | Zack Boyd | Christiansburg |
| U | Chris Cook | Heritage |
Offense
Second Team
| QB | O.B. Blake | Liberty |
| QB | Dere Hicks | William Fleming |
| RB | Chris Cook | Heritage |
| RB | Andre Hairston | Salem |
| RB | Darrin McKenzie | Brookville |
| WR | Mijuan Curtis | William Fleming |
| WR | Jacques Laboone | Christiansburg |
| TE | Judd Carte | Hidden Valley |
| C | John Loflen | Lord Botetourt |
| G | Trey Parris | Pulaski County |
| G | Darryl Robertson | Liberty |
| T | Thomas Boddie | William Fleming |
| T | Adam Adkins | Pulaski County |
| K | Kyle Curbow | Hidden Valley |
| KR | Jimmy King | Hidden Valley |
Defense
Second Team
| DL | Darryl Robertson | Liberty |
| DL |
Khayri Wallace |
Prince Edward Co. |
| DL | Casey Stafford | William Byrd |
| DE | Jerome Fleming | William Fleming |
| DE | Daniel Brown | William Byrd |
| LB | Andrew Sellers | Cave Spring |
| LB | Lamar White | Gretna |
| LB | Travis Tolley | Liberty |
| LB | Jeff Crews | Brookville |
| DB | Michael Martin | Jefferson Forest |
| DB | Steven Cobbs | Pulaski County |
| DB | Mijuan Curtis | William Fleming |
| DB | Triston Bennett | Gretna |
| P | Shawn Sturm | Jefferson Forest |
Honorable Mention
| QB | Matt Shawver | Salem |
| QB | Andrew Hoffer | Christiansburg |
| RB | Terrance Banks | Buckingham Co. |
| RB | Rico Reynolds | Gretna |
| RB | Aaron Conner | William Byrd |
| RB | Terrell Burkes | Christiansburg |
| RB | Alex Lemmer | Cave Spring |
| RB | Vincent Moore | Amherst County |
| RB | Dwayne Priest | William Fleming |
| RB | Darryl Goode | Prince Edward Co. |
| WR | Matt Short | Gretna |
| WR | Jason Myers | Gretna |
| WR | Tony Spradlin | Salem |
| WR | Ryan Jackson | Brookville |
| WR | Deontae Cobbs | Jefferson Forest |
| TE | Patrick Parziale | Jefferson Forest |
| TE | Willie Scott | Prince Edward Co. |
| TE | Lance Tate | Northside |
| C | Teddy Dyer | Salem |
| G | Ray Williams | Blacksburg |
| G | Tyson Scott | Gretna |
| T | Owen Thulin | Heritage |
| T | Marco Young | Amherst County |
| T | John Turpin | Buckingham Co. |
| T | Daniel Brown | William Byrd |
| K | Jeremy Theis | Northside |
| KR | Quinton Giles | Heritage |
| DL | Adam DeGenarro | Salem |
| DL | Matt Ballinger | Alleghany |
| DL | Kevin Rosser | Amherst County |
| DL | William Lloyd | Jefferson Forest |
| DL | D.L. Johnson | Liberty |
| DL | Matt Davis | Cave Spring |
| DL | Greg Matthews | Hidden Valley |
| LB | Leon Glover | Buckingham Co. |
| LB | Matt Greenway | Hidden Valley |
| LB | Rashad Simmons | Pulaski County |
| LB | Derek Besase | Northside |
| LB | Justice Allen | Alleghany |
| LB | Devin Deane | Lord Botetourt |
| DB | Bosco Williams | Alleghany |
| DB | Steven Markham | William Byrd |
| DB | Wayne Ford | Heritage |
| DB | Joey Daniels | Salem |
| DB | Jordon Collins | Christiansburg |
| P | Thomas Kessler | William Byrd |